HORDB

ID: hor006091
Uniprot ID: O62827(105-120)
Protein name: Proadrenomedullin N-20 terminal peptide
Gene name: ADM
Organism: Bos taurus (Bovine)
Family: Adrenomedullin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0031700 adrenomedullin receptor binding
GO BP: GO:0003073 regulation of systemic arterial blood pressure; GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0010460 positive regulation of heart rate; GO:1990410 adrenomedullin receptor signaling pathway
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: ARLDVAAEFRKKWNKWALSR
Length: 16(105-120)
Propeptide: MKLVPVALLYLGSLAFLGVDTARLDVAAEFRKKWNKWALSRGKRELRESSSYPTGLADVKAGPVQTLIRPQDVKGASRSPQASSPDAARIRVKRYRQSLNNFQGLRSFGCRFGTCTVQKLAHQIYHFTDKDKDGSAPRSKISPQGYGRRRRRSLPEAGLGRTLLQPPEPKLRGAPDSRVHQVLATLRI
Signal peptide: MKLVPVALLYLGSLAFLGVDT
Modification: T20 Arginine amide
Glycosylation: NA
Mutagenesis: NA

Function: Hypotensive peptide. May function as a hormone in circulation control (By similarity).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006091_AF2.pdb

hor006091_ESM.pdb

Mass:	278494	Formula:	C112H177N35O27
Absent amino acids:	CGHIMPQTY	Common amino acids:	A
pI:	11.65	Basic residues:	6
Polar residues:	2	Hydrophobic residues:	10
Hydrophobicity:	-82.5	Boman Index:	-5822
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	73.5
Instability Index:	2962.5	Extinction Coefficient cystines:	11000
Absorbance 280nm:	578.95

PubMed ID: 9585168
Title: Cloning of bovine preproadrenomedullin and inhibition of its basal expression in vascular endothelial cells by staurosporine.
PubMed ID: 11754956
Title: Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated from bovine adrenal medulla.